Mechanical Ventialtion (MV) and Pulmonary Mechanics

  1. Problem: Mechanical ventilation (MV) therapy is inconsistent and results in increased cost and mortality . The main problem is that there are no standardised, effective approaches to applying MV as there is no way for doctors to “see inside” the lung.

  2. Solution: A patient-specific model of pulmonary mechanics would allow clinicians to balance increased pressure support with risk of damaging healthy portions of the lung.

  3. Current Research Status: the UC and ULG teams have developed unique, clinically validated models of pulmonary mechanics for guiding MV therapy in critical illness . The HFU team have their own models and clinical approaches . Both are creating novel protocols for MV to improve care and outcome. This work requires more research investment in modeling and clinical trials to prove the concept and design final solutions.

  4. Goal: Create and test the first model-based MV protocol and clinically test it in multiple hospitals in the EU and NZ to prove the concept.

  5. Major Research Tasks:

  • Transfer modeling and computational technology between NZ and EU participants

  • Develop model-based MV protocols using existing UC, HFU and ULG clinical data

  • Test and optimise results in clinical trials in EU and NZ to prove safety, efficacy and improvements in patient outcomes.

Related eTime results on the Publications page!